Multiple CNS Therapies Advancing
An advanced pipeline that’s closer to where you live than you might expect.
cvn424
(Adjunctive & monotherapy)
cvn766
(Negative and cognitive symptoms)
CVN293
(Disease modification)
CVN398
(Disease modification)
Target-18
(Disease modification)
Target-26
(Disease modification)
Multiple Early Targets
The CVN424/GPR6 relationship uniquely limits collateral impact to surrounding genes.
45% Increase in OFF time efficacy and up to 150% reduction in common side effect compared to current treatment options.
Target:
GPR6 - an inverse agonist for parkinson’s disease
Study Focus:
GPR6 - an inverse agonist for parkinson’s disease
Highlight:
GPR6 - an inverse agonist for parkinson’s disease
Our approach differs radically from dopamine agonists currently being used and studied elsewhere to treat broad spectrum targets with highly undesirabl e side effects. CVN424 is an inverse agonist that targets GPR6, a novel gene we’ve identified using our NETSseq Platform. GPR6 is highly selectively expressed in striatal medium spiny neurons only on the indirect pathway of the basal ganglia circuit. By targeting this essential mechanism Parkinson’s patients can experience significant improvements in disease “off time”, with significant reduction in adverse side effects compared to current dopaminergic treatment options.
Learn moreThe CVN424/GPR6 relationship uniquely limits collateral impact to surrounding genes.
45% Increase in OFF time efficacy and up to 150% reduction in common side effect compared to current treatment options.
Target:
GPR6 - an inverse agonist for parkinson’s disease
Study Focus:
GPR6 - an inverse agonist for parkinson’s disease
Highlight:
GPR6 - an inverse agonist for parkinson’s disease
Our approach differs radically from dopamine agonists currently being used and studied elsewhere to treat broad spectrum targets with highly undesirabl e side effects. CVN424 is an inverse agonist that targets GPR6, a novel gene we’ve identified using our NETSseq Platform. GPR6 is highly selectively expressed in striatal medium spiny neurons only on the indirect pathway of the basal ganglia circuit. By targeting this essential mechanism Parkinson’s patients can experience significant improvements in disease “off time”, with significant reduction in adverse side effects compared to current dopaminergic treatment options.
Learn moreThe CVN424/GPR6 relationship uniquely limits collateral impact to surrounding genes.
45% Increase in OFF time efficacy and up to 150% reduction in common side effect compared to current treatment options.
Target:
GPR6 - an inverse agonist for parkinson’s disease
Study Focus:
GPR6 - an inverse agonist for parkinson’s disease
Highlight:
GPR6 - an inverse agonist for parkinson’s disease
Our approach differs radically from dopamine agonists currently being used and studied elsewhere to treat broad spectrum targets with highly undesirabl e side effects. CVN424 is an inverse agonist that targets GPR6, a novel gene we’ve identified using our NETSseq Platform. GPR6 is highly selectively expressed in striatal medium spiny neurons only on the indirect pathway of the basal ganglia circuit. By targeting this essential mechanism Parkinson’s patients can experience significant improvements in disease “off time”, with significant reduction in adverse side effects compared to current dopaminergic treatment options.
Learn moreSolengepras
(CVN424)
Target:
GPR6
Indication:
Parkinson’s disease
Highlight:
Significant reduction (1.59-hours) in OFF time versus baseline with low rates of dopaminergic side effects
Solengepras is a potentially first-in-class non-dopaminergic therapy in Phase 3 development for Parkinson's disease. Solengepras aims to reduce periods of symptomatic worsening (“OFF time”), while mitigating the side effects commonly associated with many dopaminergic therapies. Given its unique mechanism of action, favorable tolerability, and clinically meaningful (greater than one hour reduction in OFF time) activity observed in our Phase 2 clinical trial as an adjunctive therapy, solengepras has the potential to become a differentiated therapy for all patients with Parkinson's disease.
Learn moreCVN766
Target:
Orexin-1 receptor
(Ox1R)
Indication:
Psychiatric and CNS-controlled metabolic disorders
Highlight:
Generally safe and well tolerated
CVN766 is designed to be a highly selective oral antagonist of Ox1R, a target with broad therapeutic potential across CNS-controlled metabolic and psychiatric disorders. CVN766 has shown to be over 1,000-times more selective to Ox1R over orexin-2 (Ox2R) in vitro, and this specificity can potentially mitigate the off-target effect of somnolence observed in competitor compounds. CVN766 has demonstrated efficacy in multiple preclinical models and may benefit CNS-controlled metabolic disorders, such as binge eating disorder, as wells as psychiatric disorders, including schizophrenia.
Learn moreCVN293
Target:
KCNK13
Indication:
FTD/Neurodegenerative disorders
Highlight:
Potential to address well characterized inflammatory pathway, but with a CNS targeted approach
CVN293 is a highly selective oral inhibitor targeting KCNK13, a potentially novel intervention point for neurodegenerative disorders driven by neuroinflammation. KCNK13, a potassium channel identified through NETSseq, is solely expressed in microglia, the CNS’s primary immune cells. Importantly, KCNK13 has not been associated with significant expression in peripheral tissues which may translate to better tolerability relative to other approaches targeting NLRP3, which is expressed in the peripheral immune system. CVN293 is designed to inhibit KCNK13 to reduce neuroinflammation as a potentially disease- modifying therapy for neurodegenerative disorders, such as Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease.
Learn moreTarget 20
Target:
GPR6 - an inverse agonist for parkinson’s disease
Indication:
GPR6 - an inverse agonist for parkinson’s disease
Highlight:
GPR6 - an inverse agonist for parkinson’s disease
Our approach differs radically from dopamine agonists currently being used and studied elsewhere to treat broad spectrum targets with highly undesirabl e side effects. CVN424 is an inverse agonist that targets GPR6, a novel gene we’ve identified using our NETSseq Platform. GPR6 is highly selectively expressed in striatal medium spiny neurons only on the indirect pathway of the basal ganglia circuit. By targeting this essential mechanism Parkinson’s patients can experience significant improvements in disease “off time”, with significant reduction in adverse side effects compared to current dopaminergic treatment options.
Learn moreCVN424
Target:
GPR6 - an inverse agonist for parkinson’s disease
Indication:
GPR6 - an inverse agonist for parkinson’s disease
Highlight:
GPR6 - an inverse agonist for parkinson’s disease
Our approach differs radically from dopamine agonists currently being used and studied elsewhere to treat broad spectrum targets with highly undesirabl e side effects. CVN424 is an inverse agonist that targets GPR6, a novel gene we’ve identified using our NETSseq Platform. GPR6 is highly selectively expressed in striatal medium spiny neurons only on the indirect pathway of the basal ganglia circuit. By targeting this essential mechanism Parkinson’s patients can experience significant improvements in disease “off time”, with significant reduction in adverse side effects compared to current dopaminergic treatment options.
Learn morePatient Resources:
We encourage connecting with organizations that focus on CNS diseases. Below you’ll find learning opportunities, ideas on ways to care for and support those with diseases caused by CNS disorders as well as how to become a part of important research.