Cerevance Establishes Strategic Research Collaboration with Merck for the Discovery of Novel Targets in Alzheimer’s Disease

Cerevance to concurrently out-license one discovery-stage program

Boston, MA – AUGUST 9, 2022 – Cerevance, a private, clinical-stage drug discovery and development
company focused on central nervous system (CNS) diseases, today announced a multi-year strategic
research collaboration with Merck, known as MSD outside the United States and Canada, to identify novel
targets for Alzheimer’s disease utilizing Cerevance’s proprietary Nuclear Enriched Transcript Sort
sequencing (NETSseq) technology platform. Cerevance will concurrently out-license one discovery-stage
program to Merck as part of the collaboration.

Under the terms of the agreement, Cerevance will receive a $25 million upfront payment and is eligible
to receive development and commercial milestone payments totaling approximately $1.1B, in addition to
potential royalties on sales of approved products derived from the collaboration.

“The establishment of this collaboration with Merck, which comes on the heels of our positive Phase 2
data for CVN424 in patients with Parkinson’s disease, represents a significant milestone for Cerevance
and reinforces the promise of our NETSseq technology platform,” said Mark Carlton, Ph.D., chief scientific
officer of Cerevance. “We believe we are well-positioned to identify novel targets for neurodegenerative
diseases and look forward to collaborating with Merck to potentially bring forward transformative
therapeutics for patients with Alzheimer’s disease.”

“Progress in our understanding of the biology of neurodegenerative diseases continues to reveal
compelling new mechanisms for potential therapeutic intervention,” said Jason M. Uslaner, Ph.D., vice
president and head of neuroscience discovery, Merck Research Laboratories. “We look forward to
advancing the discovery program as well as taking advantage of the NETSseq platform to identify new
targets with the team at Cerevance.”

To date, Cerevance’s NETSseq technology platform has isolated and allowed for analysis of specific cell
populations in thousands of post-mortem, healthy and diseased human brain tissue samples across a
range of ages and brain regions. These analyses of human brain tissue can expose biological pathways
underlying neurodegenerative and psychiatric diseases that would be difficult to see in animal models or
differentiated human stem cells. As a result, Cerevance’s platform can reveal novel therapeutic targets
that can be modulated to correct neural circuitry or slow the disease process.

About Cerevance

Cerevance is a private pharmaceutical company whose lead therapeutic, CVN424, a first-in-class, oral,
non-dopaminergic compound acting on a novel target (GPR6), recently demonstrated significant and
clinically meaningful efficacy in a 135-patient Phase 2 study in patients with Parkinson’s disease. The
company uses its proprietary NETSseq technology platform to highly selectively identify novel target
proteins that are either over- or under-expressed in diseased brains. Partnering with over 20 brain banks
and evaluating more than 11,000 human post-mortem brain tissue samples, Cerevance is advancing a
robust pipeline of targeted treatments for patients with neurodegenerative diseases, including
Parkinson’s disease and Alzheimer’s disease. For additional information, please visit
www.cerevance.com.

Contacts

Cerevance:
Johnna Simoes, ir@cerevance.com

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Cerevance to Present During the 5th Annual LSX World Congress USA

Boston, MA – June 16, 2022 – Cerevance, a private, clinical-stage drug discovery and development company focused on central nervous system (CNS) diseases, today announced that Carrie Cook, chief business officer (CBO) of Cerevance, will participate in a fireside chat during the 5th Annual LSX World Congress USA being held in Boston, MA, June 21-22. Ms. Cook will share her thoughts around the evolving mergers and acquisitions (M&A) landscape, including how to prepare for a successful merger and how to best integrate teams and cultures from both parties involved.

Presentation Details:

Title: “Expert Insight Fireside chat: Merging of teams, cultures and assets – when M&A makes sense and how to prepare”
Date: Wednesday, June 22, 2022
Time: 3:30 p.m. ET

Speakers:

  • Carrie Cook – CBO of Cerevance
  • Douglas Fambrough – Former CEO of Dicerna
  • Chuck Triano – CFO of Xalud Therapeutics
  • Ruta Laukien – Managing Partner of Graybella Capital

For more information and registration details, see the LSX website here.

About Cerevance

Cerevance is a private pharmaceutical company whose lead therapeutic, CVN424, a first-in-class compound acting on a novel target, recently demonstrated significant and clinically meaningful efficacy in a 135-patient phase 2 study in Parkinson’s Disease. The company uses its proprietary NETSseq platform to highly selectively identify novel target proteins that are either over- or under-expressed. Partnering with over 20 brain banks and evaluating more than 11,000 brain tissue samples, Cerevance is advancing therapeutics with novel mechanisms of action for diseases such as Parkinson’s, amyotrophic lateral sclerosis (ALS), and Alzheimer’s. For additional information, please visit www.cerevance.com.

Contacts

Cerevance:
Johnna Simoes, ir@cerevance.com

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Cerevance to Participate in Panel Discussion During the 2022 BIO International Convention

Boston, MA – June 8, 2022 – Cerevance, a private, clinical-stage drug discovery and development company focused on central nervous system (CNS) diseases, today announced that Craig Thompson, chief executive officer of Cerevance, will participate in a panel discussion during the 2022 BIO International Convention being held in San Diego, CA, June 13-16. Mr. Thompson will present at the panel titled, “CNS drug development: Do biomarkers hold the future for patients?” and will share his insights on the future of neurological drug development alongside other leading CNS experts in the life sciences industry.

Panel Details:

Title: “CNS drug development: Do biomarkers hold the future for patients?”
Moderator: Allison DeAngelis, STAT News Reporter
Date: Wednesday, June 15, 2022
Time: 1:45 p.m. PT – 2:45 p.m. PT

Panelists:

  • Craig Thompson, M.B.A. – CEO of Cerevance
  • Dolo Diaz, Ph.D. – VP, Development Sciences of Denali Therapeutics
  • Dhivya Venkat – CEO of Esya Labs
  • Amit Etkin, M.D., Ph.D. – Co-Founder and CEO of Alto Neuroscience

For more information and registration details, see the BIO website here.

About Cerevance

Cerevance is a private pharmaceutical company whose lead therapeutic, CVN424, a first-in-class compound acting on a novel target, recently demonstrated significant and clinically meaningful efficacy in a 135-patient phase 2 study in Parkinson’s Disease. The company uses its proprietary NETSseq platform to highly selectively identify novel target proteins that are either over- or under-expressed. Partnering with over 20 brain banks and evaluating more than 11,000 brain tissue samples, Cerevance is advancing therapeutics with novel mechanisms of action for diseases such as Parkinson’s, amyotrophic lateral sclerosis (ALS), and Alzheimer’s. For additional information, please visit www.cerevance.com.

Contacts

Cerevance:
Johnna Simoes, ir@cerevance.com

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Cerevance Announces Leadership Transition to Implement Next Phase of Growth in Advancing Novel Therapeutics for Brain Diseases

Craig Thompson Appointed Chief Executive Officer
Founder Brad Margus Assumes Role of Executive Chairman of the Board

Boston, MA – April 19, 2022 – Cerevance, a private, clinical-stage drug discovery and development company focused on central nervous system diseases, today announced the appointment of Craig Thompson to chief executive officer. Mr. Thompson brings over 25 years of commercial and marketing leadership experience in the biotech and pharmaceutical industries to the company. Brad Margus will transition from CEO to Executive Chairman of the Board at the end of April.

“It’s been a privilege to lead our talented team over the last six years. Together, we have scaled a powerful target discovery platform, assembled a top-tier group of investors and advanced a portfolio of novel therapeutics to clinical proof of concept,” said Mr. Margus. “Now, Craig’s robust track record of executing later-stage clinical development and leading commercialization of pharmaceutical products will ensure that Cerevance succeeds in its next phase of growth. I look forward to supporting the company as Executive Chairman going forward.”

“I’m thrilled to be joining the Cerevance team as CEO,” said Mr. Thompson. “The company is on the cusp of translating exciting new therapeutic targets into potential clinical treatments that hold real promise for millions of people suffering from neurological and psychiatric diseases. The data from our recent CVN-424 Phase 2 clinical study in Parkinson’s disease validates our development platform.”

Mr. Thompson most recently served as President and CEO at Neurana Pharmaceuticals, a private company focused on the treatment of neuromuscular conditions. Prior to Neurana, he served as President and CEO of Anthera Pharmaceuticals, and before that, as chief operating officer of Tetraphase Pharmaceuticals, where he oversaw the development and implementation of the marketing, access, reimbursement and sales strategy, as well as business development and commercial manufacturing. Prior to Tetraphase, he was chief commercial officer for Trius Therapeutics, which was acquired by Cubist Pharmaceuticals for more than $700 million. Earlier in his career, Mr. Thompson served in various commercial and marketing roles of increasing responsibility at Pfizer and Merck. He holds a Bachelor of Commerce degree from McMaster University and an M.B.A. from the University of Notre Dame.

About Cerevance

Cerevance is a private pharmaceutical company whose lead program, CVN424, a first-in-class compound acting on a novel target, recently demonstrated significant and meaningful efficacy in a 135-patient phase 2 study in Parkinson’s Disease. The company uses its NETSseq transcriptional and epigenetic profiling platform to examine neuronal and glial cell populations in thousands of human donor brain tissue samples obtained from over 20 brain bank partners around the world. Then, drawing on its comprehensive understanding of the molecular characteristics of specific cell types, Cerevance is advancing a pipeline of therapeutic programs against novel targets that address the selective cellular vulnerability of neurodegenerative disease, reduce neuroinflammation without perturbing the peripheral immune system, and normalize dysfunctional circuits that are at the root of many motor and behavioral disorders.

Contacts

Cerevance:
Robert Middlebrook, +1-408-220-5722

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Cerevance Reports Positive Phase 2 Clinical Trial Results with CVN424, a Parkinson’s Disease Drug Working Through a New Mechanism

Demonstrates the Power of Cerevance’s Deep Understanding of Specific Human Brain Cell Types

Boston, MA – March 31, 2022 – Cerevance, a private, clinical-stage drug discovery and development company focused on central nervous system diseases, today announced the completion of its Phase 2 clinical trial of CVN424, the company’s first-in-class, once-a-day, orally-delivered compound in development for the treatment of Parkinson’s disease. Beyond meeting safety objectives, the drug achieved a significant and meaningful, dose-dependent reduction of “OFF time,” which refers to periods of the day when Parkinson’s symptoms recur despite medication. It also had an encouraging side-effect profile.

CVN424 was evaluated in a randomized, double-blind, placebo-controlled multicenter Phase 2 study at two dose levels in Parkinson’s disease patients with motor fluctuations. Approximately 135 subjects with Parkinson’s disease, on a stable dosage of levodopa and other Parkinson’s medications but with at least two hours or more per day of average OFF time, were enrolled. Following baseline safety and efficacy assessments, subjects were randomized to receive once-daily doses of low-dose CVN424, high-dose CVN424 or matching placebo for four weeks.

At the high dose, CVN424 showed a 1.3-hour improvement in OFF time compared to placebo (p=0.042) at four weeks. This was accompanied by an increase in ON time without Troublesome Dyskinesia, without a meaningful worsening of ON time with Troublesome Dyskinesia. Efficacy improved at four weeks versus at two weeks, and daytime sleepiness as measured by the Epworth Sleepiness Scale was reduced compared to placebo, differentiating it from most Parkinson’s disease drugs used as adjuncts to levodopa. At the lower dose, CVN424 also demonstrated a meaningful improvement in OFF time and ON time without Troublesome Dyskinesia compared to placebo. The most common adverse reactions were nausea, vomiting and headache, occurring in two subjects (4%) each at the higher dose. All other adverse reactions occurred in one subject or less.

“We are delighted to report these results which we believe demonstrate that CVN424 can provide a significant improvement for patients, with little exacerbation of dopaminergic side effects,” said Brad Margus, chief executive officer of Cerevance. “We look forward to rapidly advancing CVN424 into several larger clinical studies aimed at obtaining regulatory approval.”

Mark Carlton, Ph.D., chief scientific officer of Cerevance, added, “CVN424’s positive results demonstrate the power of the deep, cell-type-specific transcriptional and epigenetic data we are generating by applying our NETSseq platform technology to thousands of post-mortem human brain tissue samples. These data also increase the confidence we have in our pipeline of additional programs against novel targets identified by our approach.”

“For more than 50 years, physicians have relied on therapeutics that work by directly increasing dopaminergic signaling,” said Karl Kieburtz, M.D., President of Clintrex, a group of clinical development and regulatory experts who have collectively led more than 75 international multicenter clinical trials of treatments for movement disorders and neurodegenerative diseases involving tens of thousands of patients. “This new mechanism holds great promise for treating the motor fluctuations eventually experienced by all Parkinson’s disease patients, as well as potential for treating patients in the earlier stages of the disease.”

Cerevance intends to pursue additional Phase 2/3 clinical studies with CVN424 to establish a clear path to regulatory approval of the drug for adjunctive therapy. In parallel, the company will evaluate the drug’s promise as stand-alone treatment for recently diagnosed patients not yet treated with levodopa.

About Cerevance

Cerevance, a private, clinical-stage pharmaceutical company focused on brain diseases, is applying a new technology called NETSseq to reveal transcriptional and epigenetic differences between specific cell types in post-mortem human brain tissue acquired from donors whose ages varied from eight to 104 years old. NETSseq profiles neuronal and glial cell populations at depths not possible with other approaches, generating unprecedented data sets and insights. The company has thus far partnered with more than 20 brain banks around the world to assemble a growing collection of more than 10,000 clinically annotated samples from healthy and diseased donors. By applying NETSseq to specific cell types critical to circuits disrupted by disease and comparing vulnerable and resilient cell populations, Cerevance’s scientists have begun identifying targets and advancing a pipeline of novel therapeutics that modulate them to treat CNS diseases.

Contacts

Cerevance:
Robert Middlebrook, +1-408-220-5722

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Cerevance Doses First Subjects in Phase 1 Clinical Trial of CVN766

Study will evaluate safety and pharmacokinetics of potential treatment for psychiatric disorders

Boston, MA – January 25, 2022 – Cerevance, a private, clinical-stage drug discovery and development company focused on central nervous system diseases, today announced the dosing of the first human subjects in a Phase 1 clinical trial of its compound, CVN766.

CVN766 is a potent and highly selective small molecule antagonist of the orexin 1 receptor (Ox1R), a target with genetic links to panic disorder that is expressed in areas of the brain important for regulating fear, anxiety, reward and emotion. When stimulated, orexigenic neurons cause anxiety, while antagonizing Ox1R reduces this effect. CVN766 was found to be effective in various animal models of psychiatric diseases, including reversing nicotine-induced stress in rodents and acute stress behaviors in non-human primate models of panic.

“Increases of orexin levels in cerebral spinal fluid and plasma have been seen in patients with panic disorder and in a subset of patients with schizophrenia. Because of these phenomena, we believe there may be opportunities to stratify patients and also to employ these potential biomarkers to monitor treatment responses,” said Nicola Brice, Ph.D., director of neuroscience at Cerevance.

Cerevance chief business officer, Carrie Cook, noted, “We believe CVN766 may have an advantage over other Ox1R antagonists currently in development, given its extremely high selectivity against orexin 2.”  Cook added, “While dual orexin antagonists have previously been developed for sleep aid, we believe that CVN766’s selectivity against solely Ox1R could prove therapeutic in a range of psychiatric disorders.”

The Phase 1, randomized, double-blind, placebo-controlled trial will assess the safety, tolerability and pharmacokinetics of escalating single and multiple doses of CVN766 in healthy subjects. The company expects to complete the Phase 1 study by year-end.

Cerevance is continuing to actively enroll patients in the Phase 1 study. To learn more about this trial, please visit www.clinicaltrials.gov.

About Cerevance

Cerevance, a private, clinical-stage pharmaceutical company focused on brain diseases, is applying a new technology called NETSseq to reveal transcriptional and epigenetic differences between specific cell types in post-mortem human brain tissue acquired from donors whose ages varied from eight to 104 years old.   NETSseq profiles neuronal and glial cell populations at depths not possible with other approaches, generating unprecedented data sets and insights. The company has thus far partnered with more than 20 brain banks around the world to assemble a growing collection of more than 10,000 clinically annotated samples from healthy and diseased donors. By applying NETSseq to specific cell types critical to circuits disrupted by disease and comparing vulnerable and resilient cell populations, Cerevance’s scientists have begun identifying targets and advancing a pipeline of novel therapeutics that modulate them to treat CNS diseases.

Contacts

Cerevance:
Robert Middlebrook, +1-408-220-5722

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Neuroscience Drug Development Veteran Mike Poole, M.D., FACP, to Join Cerevance Board of Directors

Industry leader brings 30 years of senior pharmaceutical, investment and clinical neurology expertise to help shape CNS portfolio strategy

Boston, MA – September 8, 2021 – Cerevance, a private clinical-stage drug discovery and development company focused on brain diseases, today announced the appointment of Mike Poole, M.D., FACP, to Cerevance’s Board of Directors. Dr. Poole currently is Senior Advisor at RBNC Therapeutics, a venture-funded company working on precision therapeutics for neuropsychiatric disorders, and also serves as an advisor for the Alzheimer’s Disease Diagnostic Initiative for Gates Ventures. He recently served as senior advisor and head of the COVID-19 therapeutics accelerator at the Bill and Melinda Gates Foundation, and previously led external investments in the Global Health Office of the President.

Earlier in his career, Dr. Poole served as Vice President and Head of Neuroscience Innovation at AstraZeneca, and Vice President of Neuroscience Development at Wyeth and Pfizer. He was also a venture partner at Biomatics Capital and at Arch Ventures, focusing on big data and genomics-enabled advances in neuroscience. Dr. Poole earned his medical degree from the University of California San Diego School of Medicine.

“We are delighted to welcome Mike to Cerevance’s Board and look forward to benefitting from his deep expertise in developing new treatments for brain diseases,” said Brad Margus, chief executive officer of Cerevance. “His CNS drug development experiences at both large and small organizations will be invaluable as we advance our pipeline of potentially transformative medicines.”

Dr. Poole stated, “I am delighted to be joining Cerevance’s Board as the company’s NETSseq platform continues to generate rich transcriptional and epigenetic data sets to reveal novel, highly selective targets. I am eager to work with the Cerevance team to advance a number of new programs in areas of critical unmet need.”

About Cerevance

Cerevance, a private, clinical-stage pharmaceutical company focused on brain diseases, is applying a new technology called NETSseq to reveal transcriptional and epigenetic differences between specific cell types in human brains spanning nine decades in age. NETSseq profiles neuronal and glial cell populations at depths not possible with other approaches, generating unprecedented data sets and insights. The company has thus far partnered with more than 20 brain banks around the world to assemble a growing collection of more than 9,000 clinically annotated, human brain tissue samples from healthy and diseased donors. By applying NETSseq to specific cell types critical to circuits disrupted by disease and comparing vulnerable and resilient cell populations, Cerevance’s scientists have begun identifying targets and advancing a pipeline of novel therapeutics that modulate them for CNS diseases.

Contacts

Cerevance:
Robert Middlebrook, +1-408-220-5722

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Cerevance Appoints Naidong Ye, Ph.D. as Vice President and Head of Chemistry, Manufacturing and Controls

Will lead scale-up and production as Cerevance advances multiple clinical-stage programs

Boston, MA – February 10, 2021 – Cerevance, a private drug discovery and development company focused on brain diseases, today announced the appointment of Naidong Ye, Ph.D., a seasoned chemist with extensive pharmaceutical industry experience, as vice president and head of chemistry, manufacturing and controls (CMC).

Prior to joining Cerevance, Dr. Ye served as vice president of CMC for Millendo Therapeutics, a clinical stage biopharmaceutical company focused on developing novel treatments for endocrine diseases. While at Millendo, Dr. Ye was responsible for all CMC-related activities, including two late-stage programs. Before Millendo, Dr. Ye was senior director, head of CMC operations for AstraZeneca’s Neuroscience Innovative Medicines (NS iMed), where he led CMC operations for all small molecule development projects. In this role, Dr. Ye was responsible for projects ranging from candidate drug nomination to large scale, global pivotal trials. Earlier in his career, Dr. Ye served as chief technology officer for Dongguan Jinmeiji Pharmaceutical Co., and held leadership positions as both a scientist and CMC lead at several life sciences companies, including Pharmos Corporation, ViroPharma and Nycomed.

“It is with great pleasure that we welcome Naidong to Cerevance as we continue making significant progress in both our clinical development and drug discovery efforts,” said David H. Margolin, senior vice president of clinical and translational medicine at Cerevance. “His expertise in the production and formulation of small molecule pharmaceuticals for CNS indications will be invaluable as we prepare to conduct Phase 2 and first-in-human studies of several novel compounds this year.”

Dr. Ye commented, “Cerevance’s rapid progress in finding new druggable targets and compounds that modulate them has created a pipeline of potentially transformative treatments for patients with diverse brain disorders. I welcome the challenge of formulating and supplying each drug for use in preclinical and clinical studies.”

Dr. Ye earned a Bachelor of Science degree in chemistry from Zhongshan University and a doctorate in chemistry from Ohio State University.

About Cerevance
Cerevance, a private, clinical-stage pharmaceutical company focused on brain diseases, is applying a new technology, called NETSseq, to reveal transcriptional and epigenetic differences between specific cell types in human brains spanning nine decades in age. NETSseq profiles neuronal and glial cell populations at depths not possible with other approaches, generating unprecedented data sets and insights. The company has thus far partnered with 20 brain banks around the world to assemble a growing collection of more than 8,000 clinically annotated, human brain tissue samples from healthy and diseased donors. By applying NETSseq to specific cell types critical to circuits disrupted by disease and comparing vulnerable and resilient cell populations, Cerevance’s scientists have begun identifying targets and advancing a pipeline of novel therapeutics that modulate them for CNS diseases.

Contacts

Cerevance:
Robert Middlebrook, +1-408-220-5722

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Cerevance Appoints Carrie Ann Cook as Chief Business Officer

Pharmaceutical industry veteran brings more than 20 years of global business development experience across various disease areas

Boston, MA – February 1, 2021 – Cerevance, a private drug discovery and development company focused on brain diseases, today announced the appointment of Carrie Ann Cook, a global business development executive with more than 20 years of experience in the pharmaceutical industry, as chief business officer effective February 1, 2021.

Ms. Cook most recently served as senior vice president/global head of business development at CANbridge Pharmaceuticals Inc., in Cambridge, MA. Prior to this position, she served as senior director, center for external innovation, rare disease, at Takeda Pharmaceuticals, where she led and executed research and development transactions. Ms. Cook previously served as head of global business development & licensing, MS, medical devices and global health at EMD Serono, Inc., and as global business development director, neurology and rheumatology at Merck Serono SA, in Geneva, Switzerland. Prior to that, she held various leadership positions in business development and marketing at Novartis Pharma AG in Basel, Switzerland and Baxter Healthcare SA in Wallisellen, Switzerland. Ms. Cook holds an M.B.A. from INSEAD, in France and Singapore and a B.A. in biotechnology from Duke University in Durham, NC.

“We are pleased to welcome Carrie to Cerevance’s leadership team as we leverage our target discovery platform to identify new targets for the treatment of CNS disorders,” said Brad Margus, chief executive officer of Cerevance. “Her extensive global business development experience  will be invaluable as we pursue select partnering opportunities to advance novel compounds and ultimately improve the lives of patients.”

Ms. Cook stated, “Cerevance’s novel approach has the potential to transform the CNS space at a crucial time when innovation is so desperately needed. I look forward to contributing  my skills and experience to the team as we develop innovative therapies for brain diseases.”

About Cerevance

Cerevance, a private, clinical-stage pharmaceutical company focused on brain diseases, is applying a new technology, called NETSseq, to reveal transcriptional and epigenetic differences between specific cell types in mature human brains. NETSseq profiles neuronal and glial cell populations at depths not possible with other approaches, generating unprecedented data sets and insights. The company has thus far partnered with 19 brain banks around the world to assemble a growing collection of more than 8,000 clinically annotated, human brain tissue samples from healthy and diseased donors spanning nine decades in age. By applying NETSseq to specific cell types critical to circuits disrupted by disease and comparing vulnerable and resilient cell populations, Cerevance’s scientists have begun identifying targets and advancing a pipeline of novel therapeutics that modulate them for CNS diseases.

Contacts

Cerevance:
Robert Middlebrook, +1-408-220-5722

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868

Cerevance Appoints David Lubner to Board of Directors

Life sciences industry veteran brings more than 25 years of financial and operational experience

Boston, MA – December 8, 2020 – Cerevance, a private drug discovery and development company focused on brain diseases, today announced the appointment of David Lubner, a senior finance executive with more than 25 years of experience in the life sciences industry, to Cerevance’s Board of Directors.

Mr. Lubner most recently served as executive vice president and chief financial officer of Ra Pharma, which was acquired by UCB in April of this year. Before joining Ra Pharma, he served as a member of the senior management team of Tetraphase Pharmaceuticals, Inc. and PharMetrics Inc., a leading patient-based pharmacy and medical claims data informatics company, and at ProScript, where Velcade® (bortezomib), a therapy widely used for the treatment of multiple myeloma, was discovered.

Mr. Lubner currently serves on the Board of Directors of Dyne Therapeutics (Nasdaq: DYN), a company developing life-transforming therapies for patients with serious muscle diseases, Therapeutics Acquisition Corporation (Nasdaq: RACA), a blank check company focused on the healthcare industry sponsored by RA Capital and several other private biotechnology companies. He previously served on the Board of Directors of Nightstar Therapeutics plc (Nasdaq: NITE), a company focused on the development of one-time retinal gene therapies for patients suffering from rare inherited retinal diseases, which was acquired by Biogen in June 2019. Mr. Lubner is a Certified Public Accountant. He received his B.S. in business administration from Northeastern University and an M.S. in taxation from Bentley University.

“David’s expertise across a wide range of financial, operational and corporate strategic areas, in both senior management and Board roles, will be a valuable complement to Cerevance’s Board,” said Brad Margus, chief executive officer, co-founder and board member of Cerevance. “We’re thrilled to gain his counsel as our company’s powerful target discovery platform and rapidly expanding therapeutic pipeline open new opportunities with partners and in the capital markets.”

Mr. Lubner, stated, “I am pleased to be joining Cerevance’s Board as the company works to advance novel treatments for a range of neurodegenerative and psychiatric diseases for which effective treatments are desperately needed. The company has assembled a strong team of managers, advisors and investors, and I look forward to contributing my expertise as we explore and execute on strategic opportunities.” 

About Cerevance

Cerevance, a private, clinical-stage pharmaceutical company focused on brain diseases, is applying a new technology, called NETSseq, to reveal transcriptional and epigenetic differences between specific cell types in mature human brains. NETSseq profiles neuronal and glial cell populations at depths not possible with other approaches, generating unprecedented data sets and insights. The company has thus far partnered with 19 brain banks around the world to assemble a growing collection of more than 8,000 clinically annotated, human brain tissue samples from healthy and diseased donors spanning nine decades in age. By applying NETSseq to specific cell types critical to circuits disrupted by disease and comparing vulnerable and resilient cell populations, Cerevance’s scientists have begun identifying targets and advancing a pipeline of novel therapeutics that modulate them for CNS diseases.

Contacts

Cerevance:
Robert Middlebrook, +1-408-220-5722

Media:
Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868